RGLS

12:03p ET 3/24/2022 - Benzinga

Regulus Starts Preclinical Studies In ALS Under Pact With Brigham and Women's Hospital

Mentioned:

RGLS

Regulus Therapeutics Inc (NASDAQ: RGLS) has initiated studies to evaluate a library of oligonucleotides to block miR-155 for Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's disease) under a collaboration agreement with Harvard's Brigham and Women's Hospital (BWH). 

• The agreement, effective since September 2021, encompasses the investigation of the biologic effects of miR-155 inhibitors in both in vitro and in vivo models of ALS.
• Results from these initial studies will guide future experiments' design in additional animal models of the disease and characterize their properties. 
• Preliminary data from the studies are expected in 2H of 2022.
• In animal models of ALS, miR-155 was found upregulated in microglia and associated with disease progression. Notably, miR-155 was also elevated in the spinal cord of patients with ALS. 
• Anti-miR-155 treatment suppressed disease-associated cytotoxic microglia, and resulted in robust improvement in clinically relevant disease endpoints, including prolongation of survival.
• Price Action: RGLS shares are up 1.08% at $0.29 during the market session on the last check Thursday.

© 2022 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.

Thank